Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Digitonin-Cholesterol Complex Formation : Effects of Varying the Length of the Side-chain
高木 重和大塚 英昭秋山 敏行三川 潮
著者情報
キーワード: cholesterol analogue
ジャーナル フリー

1982 年 30 巻 10 号 p. 3485-3492

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抄録
A method was designed to study complex formation between saponin and cholesterol in aqueous ethanol, and was applied, with some modifications, to examine the ability of cholesterol analogues bearing various lengths of side-chain to form complexes (digitonides) with digitonin. The results indicated that all the analogues were capable of forming digitonides regardless of the length of the side-chain, but the effectiveness of digitonide formation increased as the length of the side-chain increased. A plausible structural model is proposed for the digitonide in order to interpret these results.
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© The Pharmaceutical Society of Japan
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