Synthesis of Deoxyobtusilactone A

Abstract

Deoxyobtusilactone A was synthesized from 1-tetradecene by a route involving [3, 3]-sigmatropic rearrangement of 1, 1-dichloro-2-(2-propenoxy)-1-hexadecene, followed by Favorskii rearrangement of the resulting γ, δ-unsaturated α, α-dichloroketone.