1982 Volume 30 Issue 10 Pages 3860-3862
Cyclodextrins (CyDs) protected human erythrocytes from hemolysis induced with prochlorperazine (PCP) in isotonic solution, depending upon the magnitude of the stability constant of PCP-CyD complexes (β- > γ- > α-CyD). The primary irritation produced by PCP on the skin of guinea pigs was found to be reduced by the addition of β- and γ-CyDs, particularly by γ-CyD, while α-CyD enhanced the irritancy of PCP. The most favorable protective effect observed for the γ-CyD complex was mainly ascribable to the weak irritancy of γ-CyD itself, suggesting a great utility of γ-CyD to alleviate the PCP-induced contact dermatitis.