New Antihypertensive Agents. II. Studies on New Analogs of 4-Piperidylbenzimidazolinones

HIROYUKI OBASE; NOBUHIRO NAKAMIZO; HARUKI TAKAI; MASAYUKI TERANISHI; KAZUHIRO KUBO; KATSUICHI SHUTO; YUTAKA KASUYA; KOKI SHIGENOBU

doi:10.1248/cpb.30.474

HIROYUKI OBASE, NOBUHIRO NAKAMIZO, HARUKI TAKAI, MASAYUKI TERANISHI, KAZUHIRO KUBO, KATSUICHI SHUTO, YUTAKA KASUYA, KOKI SHIGENOBU

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Keywords: structure-activity relationship

JOURNAL FREE ACCESS

1982 Volume 30 Issue 2 Pages 474-483

DOI https://doi.org/10.1248/cpb.30.474

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Abstract

As a part of our search for new antihypertensive agents, several 4-piperidylbenzimidazolinone derivatives (I-III) were synthesized. These compounds showed only moderate antihypertensive activity in three hypertensive rat models.

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