Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Structure Determination of Violaceol-I and -II, New Fungal Metabolites from a Strain of Emericella violacea
MIKIO YAMAZAKIYUKIO MAEBAYASHI
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1982 Volume 30 Issue 2 Pages 514-518

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Abstract

A toxic metabolite, violaceol, which was isolated from the fungus, E. violacea, was found to be a mixture of two isomers. Violaceol-I (3) and -II (4) were isolated as tetraacetates through acetylation and preparative thin layer chromatography. The structures of violaceol-I and -II were determined as shown in Fig. 1 and 2, mainly by the analysis of the 1H- and 13C-nuclear magnetic resonance spectral data, especially the 13C-1H indirect spin coupling constants. Violaceols were lethal to mice and exhibited weak antimicrobial activity.

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© The Pharmaceutical Society of Japan
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