NEW HYPOTENSIVE AGENTS

Abstract

The N-alkyl derivatives (1a-c) of 2-carbamoyloxymethyl-3-(2-chlorophenyl)-6-ethoxycarbonyl-5, 7-dimethyl-4 (3H)-quinazolinone exert a potent hypotensive activity in anesthetized rabbits and in conscious spontaneously hypertensive rats (SHR). The hypotensive activity of these compounds is attributed to a calcium antagonistic action, inhibition of norepinephrine release, potentiating effect on adenosine response, effects on central nervous system, nicotinic blocking action and to functional beta-blocking action. The hypotensive effect is not mediated through excitation of adrenergic beta-receptors or muscarinic receptors.