1982 年 30 巻 3 号 p. 866-873
The nonatriaoontapeptide corresponding to the entire amino acid sequence of ostrich adrenocorticotropic hormone (ACTH) was synthesized by successive condensations of four peptide fragments ; Z (OMe)-(15-19)-OH, Z (OMe)-(11-14)-OH, Boc-(5-10)-OH and Z-(1-4)-NHNH2, with H-(20-39)-OBzl, a synthetic intermediate of ostrich-type corticotropin-like intermediate lobe peptide, followed by deprotection with 1M trifluoromethanesulfonic acid-thioanisole in TFA. The synthetic peptide exhibited an in vivo steroidogenic potency of 0.8 relative to synthetic human ACTH.