Abstract
From bagasse medium on which mycelia of Lentinus edodes (BERK.) SING. had been grown, an acidic polysaccharide (fraction C-1-2) was isolated by deproteinization, removal of nucleic acid, fractionation with barium hydroxide and DEAE-cellulose column chromatography. The purified polysaccharide consisted mainly of xylose, arabinose, mannose, galactose, glucose and uronic acid in a molar ratio of 1.4 : 0.7 : 2.0 : 0.9 : 1.0 : 1.5. The tumor inhibition ratio of the polysaccharide against solid sarcoma 180 was 87.9% in mice given doses of 100 mg/kg×10 d by intraperitoneal administration and the tumors in 5 of 10 mice completely regressed.
