Analysis of Sodium Liothyronine in Tablets

抄録

A study on the determination of sodium liothyronine in tablets by colorimetry is described. The method is based on the iodine-starch (potato) reaction after ignition of the sample with potassium carbonate. For the ignition procedure, effeotive mixing of the sample and potassium carbonate, each previously pulverized, in an agate mortar was essential if reproducible results were to be obtained. The conditions of the iodine-starch reaction were optimized for application to a dosage level as low as 5 μg of sodium liothyronine in a tablet. The accuracy and recovery of the proposed method are satisfactory for practical pharmaceutical analysis.