Studies on Pyrimidine Derivatives. XXVII. Synthesis of 2- and 4-Pyrimidinyl Ketones by Means of the Hydration of Alkynylpyrimidines
キーワード:
hydration of acetylenic bond
1982 年 30 巻 5 号 p. 1865-1867
詳細
1982 年 30 巻 5 号 p. 1865-1867
In the palladium-catalyzed cross-coupling reaction of halopyrimidines with terminal acetylenes, 2- and 4-chloropyrimidines can be used as starting compounds, though their reactivity is inferior to that of 2- and 4-iodopyrimidines. The conversion of the 2- and 4-alkynylpyrimidines thus obtained into the corresponding pyrimidinylmethyl ketones was successfully achieved by consecutive treatment with piperidine and oxalic acid dihydrate.
