Gas Chromatographic-Mass Fragmentographic Determination of 5-Fluorouracil as a Metabolite of New 5-Fluorouracil Derivatives

抄録

5-Fluoro-5'-deoxyuridine and ethyl (±)-6-n-butoxy-5-fluoro-5, 6-dihydrouracil-γ-5-carboxylate are new pro-drug forms of 5-fluorouracil that have been developed as antitumor agents. A gas chromatographic-mass fragmentographic determination of the active substance 5-fluorouracil in biological materials following administration of each compound was established. The detection limit for 5-fluorouracil was 1 ng/ml of plasma and 1-5 ng/g of wet weight of visceral tissues.