NEW METHODS AND REAGENTS IN ORGANIC SYNTHESIS. 29. A PRACTICAL METHOD FOR THE PREPARATION OF OPTICALLY ACTIVE n-PROTECTED α-AMINO ALDEHYDES AND PEPTIDE ALDEHYDES

Abstract

Highly optically active N-protected α-amino aldehydes and peptide aldehydes can be conveniently prepared from the corresponding β-amino alcohols with little or no racemization by the use of a combination of sulfur trioxide-pyridine complex and dimethyl-sulfoxide in the presence of triethylamine.