Studies on Pyrimidine Derivatives. XXXII. Reaction of 4-Substituted 2, 6-Dimethylpyrimidine 1-Oxides with Phosphoryl Chloride

Abstract

The reaction of 2, 6-dimethyl-4-phenylpyrimidine 1-oxide with phosphoryl chloride gave 4-chloromethyl-2-methyl-6-phenylpyrimidine exclusively. In contrast, 2, 6-dimethyl-4-methoxypyrimidine 1-oxide and 2, 6-dimethyl-4-dimethylaminopyrimidine 1-oxide reacted with the same reagent to give the corresponding 2-chloromethylpyrimidines predominantly.