Studies on Tetrahydroisoquinolines. XX. A Novel Synthesis of 8-Aryl-1, 2, 3, 4-tetrahydroisoquinolines

Abstract

Treatment of a mixture of the p-quinol acetate (4) and aryl ethers with trifluoroacetic acid gave 8-aryl-1, 2, 3, 4-tetrahydroisoquinolines (1a-f) in good yields. Similar reaction of 4 and corypalline (3) afforded a corypalline dimer (5).