Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
ANTITUMOR ACTIVITY OF DITERPENOIDS, TRICHORABDALS A, B, AND C, AND THE RELATED COMPOUNDS : SYNERGISM OF TWO ACTIVE SITES
Manabu Node, Midori Sai, Kaoru Fuji, Eiichi Fujita, Setsuo Takeda, Norio Unemi
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Keywords: synergism
JOURNAL FREE ACCESS

1983 Volume 31 Issue 4 Pages 1433-1436

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Abstract
Antitumor activity of Rabdosia diterpenoids and the related compounds against Ehrlich ascites carcinoma has been studied. In addition to α-methylene cyclopentanone moiety, spirolactone aldehyde grouping functions as an active site in these compounds. Significant increase in activity can be attributed to synergism of two active sites in the molecule.
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© The Pharmaceutical Society of Japan
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