抄録
Cholesterol biosynthesis was examined with rat hepatic subcellular 10000×g supernatant fraction incubated with [24-3H]-lanosterol in the presence of one of twelve cholesterol analogs (1-12) including sitosterol. Cholesterol analogs (40μM) with different sizes of side chains exhibited very minor inhibitory effects (2-7%) compared with that of cholesterol (21%) on the synthesis of cholesterol from [24-3H]-lanosterol (18μM). The structure-inhibitory activity relationship of cholesterol analogs is discussed.
