Radioactive Metal Complexes of Ethylenediamine-N, N-diacetic Acid. Biodistribution of Radioactivity in Mice Bearing Tumors

Abstract

Complexes of ethylenediamine-N, N-diacetic acid (EDDA) with radioactive metal ions and ³H-labeled EDDA were prepared and the biodistribution of the radioactivity in mice bearing Ehrlich tumor was studied. Radioactive complexes studied were those of ⁵¹Cr, ⁵⁷Co, ⁵⁹Fe, ⁶⁴Cu, and ⁶⁷Ga. μ-Oxo ⁵⁷Co EDDA was prepared by treatment of ⁵⁷Co EDDA with hydrogen peroxide. The tumor/blood ratios of radioactivity indicated that ⁵⁷Co EDDA and μ-oxo ⁵⁷Co EDDA were concentrated in the tumor tissues, whereas other complexes and ³H-EDDA were not. The tumor tissues were clearly visualized in scintigrams after the administration of the ⁵⁷Co complexes to mice.