SYNTHESIS OF NEW ANTINEOPLASTIC PROSTAGLANDINS

Satoshi Sugiura; Takeshi Toru; Toshio Tanaka; Atsuo Hazato; Noriaki Okamura; Kiyoshi Bannai; Kenji Manabe; Seizi Kurozumi; Ryoji Noyori

doi:10.1248/cpb.32.4658

Satoshi Sugiura, Takeshi Toru, Toshio Tanaka, Atsuo Hazato, Noriaki Okamura, Kiyoshi Bannai, Kenji Manabe, Seizi Kurozumi, Ryoji Noyori

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Keywords: antineoplastic

JOURNAL FREE ACCESS

1984 Volume 32 Issue 11 Pages 4658-4661

DOI https://doi.org/10.1248/cpb.32.4658

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Abstract

The three-component coupling process allows a single-pot entry to protected 7-hydroxy-PGE₁ derivatives, leading to a variety of new PGs functionalized or unsaturated at C-7. The enone and dienone derivatives exhibit potent inhibitory activity on L1210 tumor cell growth in vitro.

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