Stereochemistry of the Intramolecular Cyclization Products of Methyl 2-Bromo-5-(4-hydroxyphenyl) hexanoate : Synthesis of trans- and cis-1, 4-Dimethyltetralin

Abstract

The stereochemistry of the spirodienones (2) obtained by the intramolecular cyclization of methyl 2-bromo-5-(4-hydroxyphenyl) hexanoate (1) was established by carbon-13 nuclear magnetic resonance spectral analysis and chemical transformation to trans- and cis-1, 4-dimethyltetralins (6).