Cyclization of α- and β-Alkylthio-Substituted Amines Possessing Positively Charged Carbon at the Nitrogen. A New Synthetic Method for Thiazolidines, Thiomorpholines and Dihydro-1, 4-benzothiazines

Abstract

The present paper describes the finding that α- and β-alkylthio-substituted amines possessing a positively charged carbon such as =CHPh, CO₂R and CH₂SR at the nitrogen undergo cyclization in the presence of lithium diisopropylamide or sodium hydride leading to thiazolidines, thiomorpholines and dihydro-1, 4-benzothiazines.