Factors Affecting the Dissolution of Griseofulvin Dispersed in Various Water-Soluble Polymers

Abstract

Dissolution profiles of griseofulvin (GRF) dispersed in water-soluble polymers were investigated by the paddle method, and large differences in dissolution behavior were observed with different kinds of polymers. The quantitative relationship of dissolution behavior with several properties of the polymers was investigated by the application of multiple regression analysis. It was found that the degree of crystallinity of GRF, the wetting of samples, the solubility or insolubility of water-soluble polymers in methanol, the viscosity of polymer solution and the dissolution rate of polymers were important in the analysis of dissolution mechanisms and prediction of dissolution profiles of GRF from these systems.