1984 Volume 32 Issue 5 Pages 1973-1979
Changes in the distributions and chemical forms of biological metals, copper, iron, zinc, calcium and magnesium, produced by the administration of clioquinol in rabbits were investigated. Single administration caused a decrease in plasma zinc and excretion into urine of a large amount of iron (this may have originated from iron-binding proteins such as hemoglobin). Multiple administrations increased plasma copper, which was mainly bound to ceruloplasmin. Decrease in copper in the kidney, increase in copper in the cerebrum and increase in zinc in both the kidney and liver were also observed after multiple administrations.
