Effect of Environmental Temperature on the Elimination of Theophylline

Abstract

The effect of environmental temperature on the elimination of theophylline was examined by using four male rabbits kept at 15 or 30°C. The rabbits kept at 30°C showed a decrease in the elimination of plasma theophylline compared with those at 15°C. The elimination rate of theophylline from rabbits at 30°C was about 1.5 times slower than that at 15°C. However, no difference was observed in the volume of distribution.