Hypoglycemic Activity of Aldose Reductase Inhibitor, 1-[(p-Bromophenyl) sulfonyl] hydantoin

Abstract

The hypoglycemic activity of a potent aldose reductase inhibitor, 1-[(p-bromophenyl)-sulfonyl] hydantoin (p-Br-PSH), was tested. The compound was not effective when orally administered to rabbits at a dose of 25 mg/kg, whereas statistically significant hypoglycemic activity was observed at doses of 50 and 100 mg/kg. The hypoglycemic activity of p-Br-PSH, however, was lower than that of tolbutamide.