Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Effect of Environmental Temperature on the Elimination of Theophylline
松山 賢治澤原 英幸野田 敦子後藤 茂井口 定男
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キーワード: therapeutic equivalence
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1984 年 32 巻 5 号 p. 2026-2029

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抄録
The effect of environmental temperature on the elimination of theophylline was examined by using four male rabbits kept at 15 or 30°C. The rabbits kept at 30°C showed a decrease in the elimination of plasma theophylline compared with those at 15°C. The elimination rate of theophylline from rabbits at 30°C was about 1.5 times slower than that at 15°C. However, no difference was observed in the volume of distribution.
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© The Pharmaceutical Society of Japan
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