OXIDATION OF 1, 3-DIMETHYL DERIVATIVES OF PYRIMIDINE BASES WITH m-CHLOROPERBENZOIC ACID

Takashi Harayama; Kayoko Kotoji; Fumio Yoneda; Tooru Taga; Kenji Osaki; Tomohisa Nagamatsu

doi:10.1248/cpb.32.2056

Takashi Harayama, Kayoko Kotoji, Fumio Yoneda, Tooru Taga, Kenji Osaki, Tomohisa Nagamatsu

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Keywords: cis 5, 6-dihydroxy-5, 6-dihydroxy-5, 6-dihydrothymine

JOURNAL FREE ACCESS

1984 Volume 32 Issue 5 Pages 2056-2058

DOI https://doi.org/10.1248/cpb.32.2056

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Abstract

Oxidation of 1, 3-dimethylthymine (1), 1, 3-dimethyluracil (2), and 5-fluoro-1, 3-dimethyluracil (3) with m-chloroperbenzoic acid were investigated. 1 gave the cis diol 5, 6-dihydrothymine derivative (4) stereoselectively. Its stereostructure was definitely determined by an X-ray analysis. 2 afforded 7, 8, and 9, and 3 afforded 8.

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