Reduction of Heterocyclic Compounds. II. Reduction of Heterocyclic Compounds with Sodium Borohydride-Transition Metal Salt Systems

Abstract

The reduction of heterocyclic compounds with the sodium borohydride-transition metal salt system was investigated. Among transition metal salts examined in this system, the sodium borohydride-nickelous chloride system was found to exhibit the strongest reducing activity. Quinoline, isoquinoline, quinoxaline and their derivatives were reduced with this system to give the corresponding tetrahydro derivatives.