Facile Preparations of 1, 4-(Diphenylmethyleneamino) piperazine-2, 5-diones and N-Phenylmethyleneamino-β, γ, and δ-lactams from Benzylidene Hydrazines and α, β, γ, and δ-Haloacyl Halides

Abstract

The reaction of benzylidene hydrazines (1) with various haloacyl halides (2) was carried out in aqueous NaOH-CH₂Cl₂ in the presence of a phase transfer catalyst to afford 1, 4-(diphenylmethyleneamino) piperazine-2, 5-diones (3) and N-phenylmethyleneamino-β, γ, and δ-lactams in yields of 31-84%.