Polycyclic N-Hetero Compounds. XVIII. Synthesis of the 11, 13, 15-Triazasteroidal Skeleton with an Oxygen Function at C-17

Abstract

N-(5, 6-Dihydro-4-benzo [h] quinazolinyl) amino acids (III and VII) were synthesized by condensation of 4-chloro-5, 6-dihydrobenzo [h] quinazoline (II) with several amino acids and were cyclized to 4, 5-dihydrobenz [h] imidazo [1, 2-c] quinazoline derivatives, i.e., 11, 13, 15-triazasteroidal compounds (IV, V, VI, VIII, and IX) using phosphoryl chloride or acetic anhydride. An oxygen function could be introduced at C-1 of 4, 5-dihydrobenz [h] imidazo [1, 2-c] quinazoline, i.e., C-17 of the 11, 13, 15-triazasteroidal compounds.