Spiropiperidines. I. Synthesis of 1'-Substituted Spiro [4H-3, 1-benzoxazine-4, 4'-piperidin]-2 (1H)-one Derivatives and Evaluation of Their Antihypertensive Activity

HARUKI TAKAI; HIROYUKI OBASE; MASAYUKI TERANISHI; AKIRA KARASAWA; KAZUHIRO KUBO; KATSUICHI SHUTO; YUTAKA KASUYA; MAKIKO HASHIKAMI; NAOKO KARASHIMA; KOKI SHIGENOBU

doi:10.1248/cpb.33.1129

HARUKI TAKAI, HIROYUKI OBASE, MASAYUKI TERANISHI, AKIRA KARASAWA, KAZUHIRO KUBO, KATSUICHI SHUTO, YUTAKA KASUYA, MAKIKO HASHIKAMI, NAOKO KARASHIMA, KOKI SHIGENOBU

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Keywords: oxazine

JOURNAL FREE ACCESS

1985 Volume 33 Issue 3 Pages 1129-1139

DOI https://doi.org/10.1248/cpb.33.1129

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Abstract

General synthetic methods for the preparation of 4-(2-aminophenyl)-4-hydroxypiperidine derivatives have been developed. The application use of these derivatives in the synthesis of 1'-substituted spiro [4H-3, 1-benzoxazine-4, 4'-piperidin]-2 (1H)-one derivatives is described, and the antihypertensive activity of the products is also reported.

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