Synthesis of Renierone, 7-Methoxy-1, 6-dimethyl-5, 8-dihydroisoquinoline-5, 8-dione and N-Formyl-1, 2-dihydrorenierone, Antimicrobial Metabolites from a Marine Sponge, Reniera sp.

Abstract

Three isoquinolinequinone antimicrobial metabolites, renierone (3), 7-methoxy-1, 6-dimethyl-5, 8-dihydroisoquinoline-5, 8-dione (4) and N-formyl-1, 2-dihydrorenierone (6), isolated from a marine sponge (Reniera sp.), were synthesized.