Synthesis and Antitumor Activity of 5-Fluoro-4-(furfurylidene aminooxy)hexahydro-2, 6-dioxo-5-pyrimidinecarboxylates

抄録

A series of 5-fluoro-t-4-[(Z)- and (E)-furfurylideneaminooxy]hexahydro-2, 6-dioxor-5-pyrimidinecarboxylates (6 and 7) was prepared by treatment of the corresponding 4-acetoxyhexa-hydropyrimidinecarboxylates 5 with (Z)- and (E)-furfuraldoximes (10 and 11), respectively, and tested for antitumor activity against murine colon carcinoma 26. The oxime ether 7c (TAC-788) showed antitumor activity against various murine tumors.