A New Method for Dissolution Testing of Vitamin E Preparations in Test Medium Containing Sodium Glycochenodeoxycholate

Abstract

A method for dissolution testing of oily and water-isoluble drug preparations was developed.It was found that dissolution testing of a preparation containing d-α-tocopherol as a model drug could be done by using the paddle method in JP X and the 2nd fluid in JP X containing 20mM sodium glycochenodeoxycholate. The data obtaiend by the methdo were useful for predicting in vivo absorption of the drug. However, in the case of a capsule containing d-α-tocopherol dissolved in cottonseed oil, the drug and vehicle floated on the surface of the disslution test medium, and good dissolution was not observed.