Studies on Peptides. CXLII. : Synthesis of Des-1-Ala-des-α-amino-Human Calcitonin Gene-Related Peptide

Abstract

Subsequent to our synthesis of human calcitonin gene-related peptide (hCGRP) (J. Chem. Soc., Chem. Commun., 1985, 602), its analog, des-1-Ala-des-α-amino-hCGRP, was synthesized. This peptide, prepared by replacement of the N-terminal Ala-Cys residues with 3-mercaptopropionic acid, followed by air oxidation, was more active than the parent peptide in respect of Ca-lowering and Pi-lowering activities in rat serum.