STEREOSELECTIVE SYNTHESIS OF TRIFLUOROMETHYLATED OLEFIN AND DIENE

Abstract

The stereoselective synthesis of trifluoromethylated z-olefins (6__∼) was achieved through the Claisen rearrangement of 1, 1, 1-trifluoropropenyl-2-carbinol derivatives (5__∼ and 7__∼). The olefins (6__∼) were converted to trifluoromethylated diene, which was used as a key intermediate in the synthesis of trifluororetinal.