Studies on Syntheses and Reactions of Methoxypyridazines. I. Methoxylation of 3, 4, 5-Trichloropyridazine

Abstract

The reaction of 3, 4, 5-trichloropyridazine (1) with 1 eq amount of NaOMe resulted in the formation of three dichloromonomethoxypyridazines (2, 3-OMe; 3, 4-OMe; 4, 5-OMe) in the ratio of 1 : 3 : 6. The 4-OMe compound 3 was isolated from the reaction mixture and the 3-OMe compound 2 was synthesized independently. Further methoxylation of 2, 3 and 4 was also investigated in order to prepare various substituted pyridazines.