Synthesis of Novel Pyridotriazepinones as Antisecretory Agents

SHIN-ICHI KODATO; HIROSHI WADA; SEIICHI SAITO; MIKIO TAKEDA; YOSHIHIKO NISHIBATA; KEIICHI AOE; TADAMASA DATE; YUICHI ONODA; HAJIME TAMAKI

doi:10.1248/cpb.35.80

SHIN-ICHI KODATO, HIROSHI WADA, SEIICHI SAITO, MIKIO TAKEDA, YOSHIHIKO NISHIBATA, KEIICHI AOE, TADAMASA DATE, YUICHI ONODA, HAJIME TAMAKI

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SHIN-ICHI KODATO
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
HIROSHI WADA
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
SEIICHI SAITO
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
MIKIO TAKEDA
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
YOSHIHIKO NISHIBATA
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
KEIICHI AOE
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
TADAMASA DATE
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
YUICHI ONODA
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
HAJIME TAMAKI
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.

Keywords: pyrido [2, 3-f] -1, 2, 4-triazepinone, pyrido [2, 3-e] -1, 2, 4-triazepinone, X-ray analysis, 1, 3, 4-oxadiazole, pyridotriazine, antisecretory activity, ring contraction

JOURNAL FREE ACCESS

1987 Volume 35 Issue 1 Pages 80-89

DOI https://doi.org/10.1248/cpb.35.80

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Abstract

In connection with the known antisecretory activity of the benzotriazepinone (1) and the pyridylurea (2), novel pyridotriazepinones (3 and 4) have been synthesized. They were prepared from aminopyridinecarboxylic acids via several steps, and their structures were confirmed by X-ray crystallographic analysis. Attempts to synthesize the positional isomer (24) resulted in formation of the pyridotriazine (25 or 26). Some of these compounds showed moderate antisecretory activity in rats.

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