Enhanced Absorption of Phenobarbital from Suppositories Containing Amino Acid and Choline Salts of Phenobarbital

Abstract

Dissolution and permeation patterns of phenobarbital (PB) from basic amino acid and choline salts of PB indicated that drug dissolution from the salts was faster than that of PB itself. Release of the drug from Vosco H15 suppositories containing the salts was faster than that from the suppository containing PB itself. After rectal administration of suppositories containing the salts to rabbits, the blood levels were significantly (p < 0.05) higher than those following administration of the suppository containing PB itself during a period from 30 min to 2 h.