Studies on as-Triazine Derivatives. IX. Synthesis of 5-Substituted 1, 2, 4-Triazine Derivatives through an Addition Reaction and Subsequent Oxidation

Abstract

The addition reactions of various nucleophiles to 6-methyl-3-phenyl-1, 2, 4-triazine (1) were investigated and a practical preparation of 1 was developed. The reactions showed many similarities to those of quinazoline (at the 4-position) and acridine (at the 9-position). The hitherto unknown compounds 5-cyano- (3), 5-carbamoyl- (5) and 5-phenacyl-6-methyl-3-phenyl-1, 2, 4-triazines (11c) were synthesized.