Benzoylthiocholine Derivatives as Substrates for Pseudocholinesterase : Synthesis and Application

MAGOHEI YAMADA; YOJI MARUI; CHOZO HAYASHI; SHOJI TAKEMURA

doi:10.1248/cpb.35.1491

MAGOHEI YAMADA, YOJI MARUI, CHOZO HAYASHI, SHOJI TAKEMURA

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Keywords: substituted benzoylthiocholine, synthetic substrate, pseudo-cholinesterase, clinical test reagent, colorimetry

JOURNAL FREE ACCESS

1987 Volume 35 Issue 4 Pages 1491-1496

DOI https://doi.org/10.1248/cpb.35.1491

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Abstract

Substituted benzoylthiocholines were synthesized and their application as reagents for clinical measurement of pseudocholinesterase was investigated. Among 21 compounds, 2, 3-dimethoxybenzoylthiocholine (19b) was found to be an excellent substrate for the measurement of the enzyme. The procedure was simple and self-hydrolysis of the substrate at the optimum pH of the enzyme was minimal.

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