Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
KINETIC RESOLUTION OF FLUOROALKYL (E) -VINYL CARBINOL DERIVATIVES BY ASYMMETRIC EPDXIDATION WITH TITANIUM-TARTRATE CATALYSTS
Yuji Hanzawa, Kei-ichi Kawagoe, Masayuki Ito, Yoshiro Kobayashi
Author information
Keywords: kinetic resolution, asymmetric epoxidation, fluoroalkyl (E) -vinyl carbinol derivatives, absolute configuration
JOURNAL FREE ACCESS

1987 Volume 35 Issue 4 Pages 1633-1636

Details
Download PDF (400K)
Download citation RIS

(compatible with EndNote, Reference Manager, ProCite, RefWorks)

BIB TEX

(compatible with BibDesk, LaTeX)

Text
How to download citation
Contact us
Abstract

Racemic fluoroalkyl (E) -vinyl carbinols (1a-d) were kinetically resolved by Sharpless epoxidation. The optical purity of the resolved alcohols was excellent (98% ee) in mono-and difluoromethyl derivatives (1b and 1c) and moderate (60% ee) in a trifluoromethyl compound (1a).

Content from these authors
© The Pharmaceutical Society of Japan
Previous article Next article
Favorites & Alerts

Recently viewed articles
Share this page
feedback
 Top