THE PHARMACOLOGICAL ACTIVITY OF CANNABINOL AND ITS MAJOR METABOLITE, 11-HYDROXYCANNABINOL

Ikuo Yamamoto; Kazuhito Watanabe; Katsunori Kuzuoka; Shizuo Narimatsu; Hidetoshi Yoshimura

doi:10.1248/cpb.35.2144

Ikuo Yamamoto, Kazuhito Watanabe, Katsunori Kuzuoka, Shizuo Narimatsu, Hidetoshi Yoshimura

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Keywords: cannabinol, 11-hydroxycannabinol, active metabolite, catalepsy, hypothermia, pentobarbital-induced sleep, locomotor activity

JOURNAL FREE ACCESS

1987 Volume 35 Issue 5 Pages 2144-2147

DOI https://doi.org/10.1248/cpb.35.2144

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Abstract

The pharmacological effects (catalepsy, hypothermia, pentobarbitalinduced sleep prolongation and effect on locomotor activity) of cannabinol and its major metabolite, 11-hydroxycannabinol were studied in mice. 11-Hydroxycannabinol was more potent than cannabinol in the pharmacological indices examined. The results indicate that 11-hydroxycannabinol can be categorized as an active metabolite of cannabinol.

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