Studies on Pyrimidine Derivatives. XXXIX. Site-Selectivity in the Reaction of 5-Substituted and 4, 5-Disubstituted Pyrimidine N-Oxides with Trimethylsilyl Cyanide

HIROSHI YAMANAKA; TAKAO SAKAMOTO; SUMIKO NISHIMURA; MATAICHI SAGI

doi:10.1248/cpb.35.3119

Studies on Pyrimidine Derivatives. XXXIX. Site-Selectivity in the Reaction of 5-Substituted and 4, 5-Disubstituted Pyrimidine N-Oxides with Trimethylsilyl Cyanide

HIROSHI YAMANAKA, TAKAO SAKAMOTO, SUMIKO NISHIMURA, MATAICHI SAGI

著者情報

キーワード: site-selectivity, pyrimidine N-oxide, trimethylsilyl cyanide, Reissert-Henze reaction, pyrimidinecarbonitrile

ジャーナルフリー

1987 年 35 巻 8 号 p. 3119-3126

DOI https://doi.org/10.1248/cpb.35.3119

詳細

抄録

The site-selectivity in the modified Reissert-Henze reaction of 5-substituted, and 4, 5-disubstituted pyrimidine 1-oxides with trimethylsilyl cyanide was examined. The reaction of 5-substituted 4-methoxypyrimidine 1-oxides with trimethylsilyl cyanide gave exclusively 2-pyrimidine-carbonitriles in good yields without exception. On the other hand, the other 5-substituted and 4, 5-disubstituted pyrimidine 1-oxides gave mainly 6-pyrimidinecarbonitriles.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）