A 19F NMR STUDY OF 2-DEOXY-2-FLUORO-D-GALACTOSE IN MICE

Yoko Kanazawa; Satoru Kuribayashi; Masaharu Kojima; Terushi Haradahira

doi:10.1248/cpb.36.4213

A ¹⁹F NMR STUDY OF 2-DEOXY-2-FLUORO-D-GALACTOSE IN MICE

Yoko Kanazawa, Satoru Kuribayashi, Masaharu Kojima, Terushi Haradahira

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Keywords: F-19 NMR, mouse, liver, 2-deoxy-2-fluoro-D-galactose, 2-deoxy-2-fluoro-D-glucose, functional diagnosis

JOURNAL FREE ACCESS

1988 Volume 36 Issue 10 Pages 4213-4216

DOI https://doi.org/10.1248/cpb.36.4213

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Abstract

The metabolic pathway of 2-deoxy-2-fluoro-D-galactose (FDGal) in mice was studied by ¹⁹F NMR. Efficient accumulation of FDGal in liver was demonstrated by NMR, which is consistent with the results of Ishiwata et al. using radioactive ¹⁸FDGal. The new discovery is that this fluorinated hexose was converted to 2-deoxy-2-fluoro-D-glucose (FDG) through UDP-FDGal and UDP-FDG apparently by the action of UDP-Gal epimerase.

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