Sodium scymnol sulfate, which is a major component in bile of Rhizoprionodon acutus, was isolated by 3 steps of chromatography to afford 753 mg of the bile salt from 5 gallbladders (65 g), and its structure was determined to be 3α, 7α, 12α, 24, 26-pentahydroxy-5β-cholestan-27-yl sodium sulfate, on the basis of chemical and physical data.
