Anti-inflammatory Constituents of Topically Applied Crude Drugs. III. Constituents and Anti-inflammatory Effect of Paraguayan Crude Drug “Tamandá cuná” (Catasetum barbatum LINDLE)

MINEO SHIMIZU; HISASHI SHOGAWA; TOSHIMITSU HAYASHI; MUNEHISA ARISAWA; SHOICHI SUZUKI; MASAO YOSHIZAKI; NAOKATA MORITA; ESTIBAN FERRO; ISABEL BASUALDO; Luis H. BERGANZA

doi:10.1248/cpb.36.4447

Anti-inflammatory Constituents of Topically Applied Crude Drugs. III. Constituents and Anti-inflammatory Effect of Paraguayan Crude Drug “Tamandá cuná” (Catasetum barbatum LINDLE)

MINEO SHIMIZU, HISASHI SHOGAWA, TOSHIMITSU HAYASHI, MUNEHISA ARISAWA, SHOICHI SUZUKI, MASAO YOSHIZAKI, NAOKATA MORITA, ESTIBAN FERRO, ISABEL BASUALDO, Luis H. BERGANZA

Author information

MINEO SHIMIZU
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
HISASHI SHOGAWA
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
TOSHIMITSU HAYASHI
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
MUNEHISA ARISAWA
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
SHOICHI SUZUKI
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
MASAO YOSHIZAKI
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
NAOKATA MORITA
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
ESTIBAN FERRO
Facultad de Ciencias Quimicas, Universidad Nacional de Asuncion
ISABEL BASUALDO
Facultad de Ciencias Quimicas, Universidad Nacional de Asuncion
Luis H. BERGANZA
Facultad de Ciencias Quimicas, Universidad Nacional de Asuncion

Keywords: anti-lammatory effect, Catasetum barbatum, Orchidaceae, 2, 7-dihydroxy-3, 4-dimethoxyphenanthrene, 2, 7-dihydroxy-3, 4, 8-trimethoxyphenanthrene, carrageenin edema, H₁-receptor

JOURNAL FREE ACCESS

1988 Volume 36 Issue 11 Pages 4447-4452

DOI https://doi.org/10.1248/cpb.36.4447

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Abstract

The 70% EtOH extract of the aerial parts of Catasetum barbatum LINDLE showed inhibitory effects on carrageenin-induced paw edema when topically applied to rats and on histamine-induced contraction in guinea pig ileum.
Four compounds including a new phenanthrene, 2, 7-dihydroxy-3, 4, 8-trimethoxyphenanthrene (2), were isolated from the active fraction. 2, 7-Dihydroxy-3, 4-dimethoxyphenanthrene (1) showed inhibitory effects in both biological assays.

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