Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Growth-Inhibitory Effect of Hexa-N-acetylchitohexanse and Chitohexaose against Meth-A Solid Tumor
AKIO TOKORONOBUHIKO TAKEWAKIKO SUZUKITAKESHI MIKAMISHIGEO SUZUKIMASUKO SUZUKI
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1988 Volume 36 Issue 2 Pages 784-790

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Abstract

Two oligosaccharides, hexa-N-acetylchitohexaose (NACOS-6) and chitohexaose (COS-6), consisting solely of N-acetyl-D-glucosamine and D-glucosamine, respectively, were found to be growth-inhibitory against Meth-A solid tumor transplanted into BALB/c mice, when each oligosaccharide was administered i.v. at a dose of more than 1 mg/kg. Mouse peritoneal macrophages elicited with casein underwent activation with these oligosaccharides in vitro to produce interleukin 1. Spleen cells from mice given these oligosaccharides also underwent acceleration of interleukin 2 production and cytolytic T-lymphocyte differentiation. Thus, the antitumor mechanism of NACOS-6 and COS-6 was assumed to involve increased production of lymphokines including interleukins 1 and 2, sequentially, leading to the manifesation of antitumor effect through proliferation of cytolytic T-lymphocytes.

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© The Pharmaceutical Society of Japan
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