抄録
Using spin label, we have studied the effects of cholesterol derivatives with a terminal hydroxyl group at the 3-position of the cholestene nucleus on the membrane structure of dilauroylphosphatidylcholine-choles-terol liposomes. The magnitude of the empirical parameter estimated from ESR spectra progressively increased with the increasing amount of cholesterol derivatives added. However, a break appeared in the slope of the parameter versus the mole ratio of the cholesterol derivatives. This indicates that the added cholesterol derivative provides a new phase which can be related to the change in the immunolysis of liposomes.
