1988 Volume 36 Issue 6 Pages 1942-1956
A new dimeric epipolythiodioxopiperazine named chetracin A with two tetrasulfide bridges was isolated from Chaetomium nigricolor and C. retardatum, and the structure (3) proposed chiefly from proton and carbon-13 nuclear magnetic resonance (1H-and 13C-NMR) data was established by X-ray analysis. Two congeners of chaetocin (2) named chaetocins B and C were isolated from C. virescens var. thielabioideum, and were proved tobe homologs with one disulfide and one trisulfide bridge (9) and with two trisulfide bridges (10), respectively, from spectral data, chiefly NMR and fast atom bombardment mass spectrometry/mass spectrometry (FAB MS/MS). The structure-activity relationships observed for the antibacterial activity and cytotoxicity of the related compounds are discussed.
