Studies on Peptides. CLIX. : Preparation of a Protected 33-Residue Peptide for the Synthesis of Human Cholecystokinin (hCCK-33)

Abstract

A protected 33-residue peptide corresponding to the entire amino acid sequence of human cholecystokinin (hCCK-33) was synthesized by successive azide condensations of 7 peptide fragments of established purity. β-Cycloheptyl aspartate [Asp(OChp)] was employed to suppress base-catalyzed succinimide formation.